Anysis

Platelet Function Test

The Anysis system test provides assessment for inherited, acquired, or drug-induced platelet dysfunction.

Through in-vivo vascular mimicking microfluidics, the system measures a realistic primary hemostasis associated with platelet function.

Total Platelet Function Assay

Bleeding Risk Screening

Anysis C/ADP test, Anysis-C/Epinephrine test
Screens platelet function for impaired primary hemostasis, such as von Willebrand disease
Provides high sensitivity for congenital platelet dysfunction, such as Glanzmann thrombasthenia

Anti-platelet response

Anysis-Aspirin test, Anysis-P2Y12 test
Assesses platelet dysfunction caused by Aspirin
Detects platelet dysfunction caused by P2Y12-receptor inhibitors

Anysis-SIPA
Assesses Shear-Induced Platelet Activation and Aggregation

Key Features of Anysis

Whole blood hemostasis assay
Similar to in vivo vascular environment
Test time: Less than 4 minutes / test
Sample volume: 200uL

Upstream-activation & downstream assay
ECM mimicked microbeads-packed tube
Platelet-aggregation induced closure
Blood migration distance-based assay

Upstream Activation - Downstream Adhesion

Activation

Adhesion

Aggregation

Occlusion

Detection

Upstream activation, which frequently occurs in pathological vascular environments, can be mimicked by adopting a shear-generating stirrer in a sample chamber.

After activation, the blood flows through a microfluidic tube including a flow-closure section consisted of ECM-coated microbeads. Typical ECMs are collagen and fibrinogen.

Adhesion of activated platelets occurs, followed by aggregation of platelets.

As the adhesion and aggregation of platelets continues, the flow paths through packed microbeads are gradually blocked and the blood flow eventually stops.

Measurement of how far the blood has migrated is the index for assessing the platelet function. The longer the distance migrated, the stronger the dysfunction of the platelets.

Anysis is a...

Operator-independent Results

Measurements are not affected by operator's skillfulness

Stenosed Thrombosis Model

Flow through microbeads mimics stenosed vascular thrombosis

Platelet-Adhesion Characteristic

Adhesion characteristic is fully emphasized in microscale pores

Fully Automated System

With a single pipetting, the whole test is automatically operated

Bubble-free Test

Air bubbles in blood sample are naturally excluded in the test

Hematocrits-independent

Hematocrit variations do not affect the measurement of Anysis