Anysis
Platelet Function Test
The Anysis system test provides assessment for inherited, acquired, or drug-induced platelet dysfunction.
Through in-vivo vascular mimicking microfluidics, the system measures a realistic primary hemostasis associated with platelet function.
ANYSIS-II
ANYSIS-300S
Total Platelet Function Assay
Bleeding Risk Screening
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Anysis C/ADP test, Anysis-C/Epinephrine test
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Screens platelet function for impaired primary hemostasis, such as von Willebrand disease
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Provides high sensitivity for congenital platelet dysfunction, such as Glanzmann thrombasthenia
Anti-platelet response
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Anysis-Aspirin test, Anysis-P2Y12 test
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Assesses platelet dysfunction caused by Aspirin
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Detects platelet dysfunction caused by P2Y12-receptor inhibitors
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Anysis-SIPA
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Assesses Shear-Induced Platelet Activation and Aggregation
Key Features of Anysis
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Whole blood hemostasis assay
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Similar to in vivo vascular environment
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Test time: Less than 4 minutes / test
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Sample volume: 200uL
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Upstream-activation & downstream assay
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ECM mimicked microbeads-packed tube
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Platelet-aggregation induced closure
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Blood migration distance-based assay
Upstream Activation - Downstream Adhesion
Activation
Adhesion
Aggregation
Occlusion
Detection
Upstream activation, which frequently occurs in pathological vascular environments, can be mimicked by adopting a shear-generating stirrer in a sample chamber.
After activation, the blood flows through a microfluidic tube including a flow-closure section consisted of ECM-coated microbeads. Typical ECMs are collagen and fibrinogen.
Adhesion of activated platelets occurs, followed by aggregation of platelets.
As the adhesion and aggregation of platelets continues, the flow paths through packed microbeads are gradually blocked and the blood flow eventually stops.
Measurement of how far the blood has migrated is the index for assessing the platelet function. The longer the distance migrated, the stronger the dysfunction of the platelets.
Anysis is a...
Fully Automated System
With a single pipetting, the whole test is automatically operated
Bubble-free Test
Air bubbles in blood sample are naturally excluded in the test
Hematocrits-independent
Hematocrit variations do not affect the measurement of Anysis
Operator-independent Results
Measurements are not affected by operator's skillfulness
Stenosed Thrombosis Model
Flow through microbeads mimics stenosed vascular thrombosis
Platelet-Adhesion Characteristic
Adhesion characteristic is fully emphasized in microscale pores
Platelet Function Tests
