Platelet Function Test
The Anysis system test provides assessment for inherited, acquired, or drug-induced platelet dysfunction.
Through in-vivo vascular mimicking microfluidics, the system measures a realistic primary hemostasis associated with platelet function.
Total Platelet Function Assay
Bleeding Risk Screening
Anysis C/ADP test, Anysis-C/Epinephrine test
Screens platelet function for impaired primary hemostasis, such as von Willebrand disease
Provides high sensitivity for congenital platelet dysfunction, such as Glanzmann thrombasthenia
Anysis-Aspirin test, Anysis-P2Y12 test
Assesses platelet dysfunction caused by Aspirin
Detects platelet dysfunction caused by P2Y12-receptor inhibitors
Assesses Shear-Induced Platelet Activation and Aggregation
Key Features of Anysis
Whole blood hemostasis assay
Similar to in vivo vascular environment
Test time: Less than 4 minutes / test
Sample volume: 200uL
Upstream-activation & downstream assay
ECM mimicked microbeads-packed tube
Platelet-aggregation induced closure
Blood migration distance-based assay
Upstream Activation - Downstream Adhesion
Upstream activation, which frequently occurs in pathological vascular environments, can be mimicked by adopting a shear-generating stirrer in a sample chamber.
After activation, the blood flows through a microfluidic tube including a flow-closure section consisted of ECM-coated microbeads. Typical ECMs are collagen and fibrinogen.
Adhesion of activated platelets occurs, followed by aggregation of platelets.
As the adhesion and aggregation of platelets continues, the flow paths through packed microbeads are gradually blocked and the blood flow eventually stops.
Measurement of how far the blood has migrated is the index for assessing the platelet function. The longer the distance migrated, the stronger the dysfunction of the platelets.