RheoSCAN

Early diagnosis of Diabetic complications and Metabolic syndrome

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Diabetic Complication Screening Assay

The best treatment starts with early detection

Normal

metabolism

Early metabolic dysregulation

Prediabetes

Type 2 Diabetes

Metabolic Syndrome

T2DM Complications

Glucose monitoring is not enough to detect T2DM(type 2 diabetic mellitus) complications.

 

The most serious problem is the late detection of the Diabetic Mellitus complications at their late stages 

RheoScan system provides clinicians with easy and rapid identification of a patient’s diabetic complication status at  point-of-care (POC) setting.

Now, RheoScan based on the innovative technology and clinical validation is ready to answers the calls from the hospitals and clinics. 

Introducing RheoSCAN 

FAST

  • Rapid testthe test takes less than a minute (30~60 seconds)

WHOLE BLOOD

  • Small volume of whole blood needed

  • Deformability(EI): 6uL + PVP Sol.

  • Critical Shear Stress(CSS): 500uL

SIMPLE & EASY

  • One step of pipetting

  • Disposable microchip

  • Automated operation

INNOVATIVE

The core technology includes:

  • Laser-diffraction

  • Microfluidic Rheometry

  • Image analysis

  • Precision fabrication

TARGETED

Patients with:

  • Diabetes Mellitus

  • Diabetic Complications

  • Diabetic Retinopathy (eye)

  • Diabetic Nephropathy (kidney)

  • Metabolic Syndrome

  • Anyone who want's to check their health status

EARLY DETECTION

  • RheoScan system shows significantly high correlation with DKD, DR, and MetS through CSS

RBC Rheology in Microcirculation

RBC Deformability

Healthy RBCs

  • Flow through a vessel which is smaller than RBCs due to deformabilit

Hardened RBCs

  • Have some difficulty in flowing small vessels, which may cause followings: Local hypertensionLocal vascular injury and sclerosisHypoxia to tissues

RBC Aggregation

Healthy RBCs

  • easy to disaggregate and enter small vessels in n efficient manners.

 

Hyper-aggregating RBCs

  • Do not dis-aggregate and cause followings: Local hypertension, vascular sclerosisHypoxia to local tissues

RBC Rheology in DM Complication

Patients with diabetes mellitus(DM) have hyperglycemia and elevated fibrinogen that leads to impaired RBC deformabilityRBC aggregation, and Cricital Shear Stress.

- Hyperglycemia leads to non-enzymatic glycation and oxidative stress which increases Glycosylated Hemoglobin Type A1C and membrane glycation, Peroxidation of lipid membrane leads to impaired red blood cell deformability. 

RheoScan can diagnose  diabetic complications such as diabetic nephropathy, diabetic retinopathy, and metabolic syndrome with RBC deformability / Critical Shear Stress.

Early Diagnosis of Diabetic Retinopathy

What is T2DM Diabetic Retinopathy? 

  • It is the most common diabetic eye complication and the leading cause of blindness in working age people.

  • Retinopathy causes vision loss in either macular edema or proliferative diabetic retinopathy

What are the symptoms?

  • Diabetic Retinopathy can be destroying the eye's blood vessels without any noticeable symptoms

Who is at risk?

  • All people with diabetes - both type1 and type2 - are at risk

RBC deformability reduction shows high correlation with retinopathy in T2DM.

RheoScan-D predicts diabetic retinopathy among type 2 diabetic patients.

RBC deformability reduction indicates 2.93 folds high risk to have diabetic to have diabetic retinopathy in T2DM.

Early Diagnosis of Diabetic Nephropathy

What are the symptoms?

  • No apparent symptoms at early stages

  • Usually appear when kidney damage to progress

  • Even then, symptoms tend to be vague

​Who is at risk?

  • All people with diabetes – both type 1 and type 2 –  are at risk

What is Diabetic Nephropathy?

  • About 25% with diabetes eventually develops diabetic nephropathy (diabetic kidney disease)

  • Diabetic nephropathy is a leading cause of kidney failure, requiring hemodialysis.

  • Local hypertension

  • Low filtration rate

  • Proteins in urine

RheoScan CSS

  • RBC Critical Shear Stress(CSS) shows high correlation with nephropathy in T2DM

  • RheoScan-CSS can screen diabetic nephropathy among type 2 diabetic patients

(X=L, Y=W)

*Patient who should be excluded 
Arthritis patient, Person who drank alcohol within 48 hours, Iron deficiency anemia, Pulmonary thrombosis, Artificial Heart, Malaria

Diabetic Complication Screening Assay - RheoSCAN-D300

*RheoScan RSD-K01 Test kit

RBC Deformability

Laser-Diffraction

*RheoScan D-300

Cytometry Part B (2006)

Biosensor &Bioelectronics (2003)

Cytometry Part B (2006)

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