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What is critical shear stress (CSS) and why is it important?

Writer's picture: RheoMeditech Inc.RheoMeditech Inc.

CSS is the minimum shear stress needed to disaggregate RBC aggregation, and appears to be an excellent index to represent RBC aggregation.


First, CSS is hematocrit-independent so hematocrit correction is not required, whereas for the CSR, the AI increases and the threshold shear-rate decreases when the hematocrit increases.


Second, CSS holding dimensional unit such as the millipascal (mPa) is a more physical value to compare directly with those measured with other devices than any other aggregation indexes. Most conventional aggregation indexes such as the M-index use arbitrary unit; therefore, the results obtained cannot be compared across studies.


Furthermore, CSS also reflects cellular factors as well as plasmatic factors. Therefore, CSS appears to be a potentially useful index to represent RBC aggregation.

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